ABSTRACT
In 40 patients with that follow or complicate portal hypertension gastropathy [PHG] and duodenopathy [PHD] of hepatic etiology, histomorphometric measurement of mucosal vascular bed area through estimation of nuclear ploidy and proliferative index of epithelial mucosal cells showed that the incidence. [PHG and PHD] were 55% and 30% respectively. These incidences were significantly higher than that of 10 non portal hypertension controls and also significantly related to the degree of oesophageal varices [grade Ill and IV] and incidence of gastropathy, but not to the Child score of liver affection. It is concluded that portal hypertension was reflected more on gastric than duodenal mucosa. PHG and PHD predisposes to gastritis and ulceration and significantly raised the proliferative activity of gastric and duodenal mucosa. Congestion, inflammation and ulceration of gastro-duodenal mucosa following portal hypertension are contributing factors enhancing mucosal proliferation
Subject(s)
Humans , Male , Female , Hypertension, Portal , Endoscopy, Gastrointestinal , Esophageal and Gastric Varices , DNA , DuodenumABSTRACT
In 31 patients with dyspepsia sonographic examination showed thick wall gallbladder in 26 [83.9%], multiple stones in 21 [67.7%] and single stone in 10 cases [32.2%]. Mucosal chronic inflammatory infiltration and mucosal ulceration were the most common lesions [87.1% and 67.7% respectively]. Dysplasia was found in 3 gallbladders [9.7%], with DNA changes showing aneuploid histogram pattern and higher values of S phase percent of cellular population. Hyperplasia was associated with increased percentage of cells occupying the S phase and increased values of 2C-deviation index and 5C exceeding rate percentage. The DNA changes were more associated with multiple stones with significant differences in S phase percentage cellular population between multiple and single stones. Thus, it is concluded that multiple gallstones is an indicator for preference of cholecystectomy to avoid development difficulty predicting malignancy of gallbladder